MYC and Burkitt lymphoma: Cytogenetically, almost all BL cases have a translocation involving the MYC gene at 8q24 with the immunoglobulin heavy chain gene (IGH) on 14q32 or less commonly with kappa light chain locus (IGK) at 2q11 or light chain locus (IGL) at 22q11 [26, 49] and the Epstein Bar Virus (EBV) associated with most aggressive cases.