Genomic profiling of Richter's syndrome, which represents a transformation of chronic lymphocytic leukemia (CLL) to aggressive lymphoma and is mostly represented by DLBCL, with a postgerminal center phenotype, shows a 13q amplification which encodes the miR-17~92 cluster which interacts with c-MYC [53]. The gene discussed is MYC; the disease is diffuse large B-cell lymphoma.