Intra-LA infusion of either ifenprodil [pERK1: t(4) = 0.173, P > .05; pERK2: t(4) = 1.273, P > .05] or 7-Ni [pERK1: t(5) = 1.772, P > .05; pERK2: t(5) = 0.332, P > .05], however, significantly impaired HFS-induced ERK activation in the LA (Figure 5(d)). The gene discussed is MAPK1; the disease is Hand-foot syndrome.