IGHE and Increased total eosinophil count: These mice developed such changes as airway inflammation, reversible airway obstruction, eosinophilia in airway tissue, increased CD4+ lymphocytess, increased CD8+ lymphocytes, mucus hyperproduction, increased allergen-specific IgE, increased Th2 cytokines, early- and late-phase responses, and mitochondrial structural and functional abnormalities [10,76,77,88,89].