A study of a well-known childhood asthma management program revealed that single nucleotide polymorphisms (SNPs) may be associated with asthma; these SNPs are found in multiple genetic loci, including importin 13 [21], VEGF [22], MMP-12 [23], Wnt [24], ORMDL3, 2PBP2/GSDMB/ORMDL3 [25-27], PDE4D [28], PRKCA [29], TGF-beta1 [30], IL-10 [31], IL-13 [32], JAG1 [33], ANKRD5 [33], IL-17 [34], IL25 [35], 12q24 [36-39], IL-12beta [40], and beta2-adrenergic receptor [41]. The gene discussed is ORMDL3; the disease is asthma.