In the 12q24 area there are other genes that might be involved in the phenotype (Additional file 3) including THRAP2, TBX5 and PTPN11 for cardiac and great vessel anomalies; TBX5, CMKLR1, and TRPV4 for skeletal defects; PRKAB1, GPR109A, and GPR109B for increased hunger and obesity. Here, HCAR2 is linked to obesity due to melanocortin 4 receptor deficiency.