To confirm the polymorphic status of reported SNPs and identify novel SNPs with potential prognostic significance, we sequenced genomic DNA within the KLK15 promoter (Figure 2B) of four ovarian (normal -HOSE17.1; cancer- OVCA432, SKOV3 and PEO1) cell lines and the germline DNA of 30 ovarian cancer patients with aggressive disease. The gene discussed is KLK15; the disease is ovarian carcinoma.