In this study, we report that 8 of 70 samples (11.4%) of triple negative breast cancers harbor EGFR mutations, including exon 19 deletions, inversions and exon 21 missense substitutions, which may predict sensitivity to EGFR tyrosine kinase drugs, thus suggesting a rationale for the clinical applicability of detecting EGFR mutations in these tumours, and potential use of EGFR tyrosine kinase inhibitor therapy. Here, EGFR is linked to triple-negative breast carcinoma.