IGHE and allergic disease: Thus, despite the close parallels between immune responses that characterize helminth infections and allergic diseases, namely increased levels of Immunoglobulin (Ig)-E, tissue eosinophilia and mastocytosis along with T cells that preferentially secrete Th2 cytokines interleukin (IL)-4, IL-5 and IL-13 [8,10-12], the clinical outcome with respect to immediate hypersensitivity and inflammation is clearly not the same [13].