A distinct association of BRAF mutations with MSI-H and the methylation of hMLH1 and MGMT was observed among serrated cases, thus corroborating the idea that BRAF-mutated CRCs (Jass groups 1 and 2) represent serrated adenocarcinomas with high accuracy,6,14,26 but the relatively low frequency of MSI-H cancers among serrated adenocarcinomas indicates that sporadic MSI-H colorectal cancers can be attributed only to a subset of serrated adenocarcinomas.4,5,14. This evidence concerns the gene MLH1 and adenocarcinoma.