Therefore, this study was conducted in order to identify the prevalence of BRAF and KRAS mutations in serrated adenomas and serrated adenocarcinomas, and their potential associations with both the microsatellite instability (MSI) status and the methylation of hMLH1 and MGMT, which are known to be altered in serrated polyps and in the sporadic MSI/methylator pathway to CRC. Here, MLH1 is linked to colorectal carcinoma.