The present study pavesthe way for further research to better understand the role of the cyclin D1 pathwayboth at the cell cycle and molecular levels in stem cell-mediated glioma therapy.Studying the effects of reduced expression of cyclin D1 after treating with hUCBSCcould potentially help us to understand the role of cyclin D1 in glioblastoma aswell as, to further delineate the human glioblastomal hierarchy, reiterating theimportance of hUCBSC in glioblastoma. The gene discussed is CCND1; the disease is central nervous system cancer.