With FACS and immunoblotanalyses, we demonstrated that cyclin D1, Cdk 4 and Cdk 6 are essential for thecells to transit the G0-G1 phase and that cyclin D1 must beexpressed to receive the mitogenic stimuli for the cells to initiate the cell cycle.Also, we found that when co-cultured with hUCBSC, glioma cells were mimicking theroles of both Fascaplysin and thymidine. This evidence concerns the gene CCND1 and central nervous system cancer.