AKT1 and glioma: The possible mechanism might be the activation ofβ-catenin by PI3k/AKT pathway as reported in HepG2 cells [41] and alveolarmacrophages [42].Earlier reports have shown that downregulation of β-catenin in osteosarcomacells and experimental rat gliomas transfected with β-catenin siRNA decreasescyclin D1 expression levels.