Similarly, when glioma cells aloneand in co-culture with hUCBSC were immunoprecipitated with Cdk 4, immuno blottedwith cyclin D1 and Cdk 6 antibodies, reduction was observed in the expressionlevels of both cyclin D1 and Cdk 6 (Fig. 4H), indicating that the hUCBSC treatment may not only reducethe individual expression of the respective genes, but also effect their complexformations, necessary for the transition from G0-G1 phaseto other phases of the cell cycle. The gene discussed is CCND1; the disease is glioma.