Studies supporting a role for Pak1 [45,46], EGFR [47], and Ack1 [20] activation/overexpression in schwannoma growth, suggests alternative strategies and rationale for the development of new therapies for these tumors based on overexpression of miR-7 or inhibition of Ack1, Pak1, and EGFR pathways. The gene discussed is TNK2; the disease is schwannoma.