In analyses involving 353 adult de novo AML patients, Carnicer et al. [36] found cooperative mutations of FLT3-TKD with CBFβ/MYH11 rearrangement (four of 15 patients) and C/EBPα with FLT3-ITD (two of 82 patients). This evidence concerns the gene FLT3 and acute myeloid leukemia.