Specifically, FLT3-ITD expression prevented FOXO3a-mediated apoptosis and upregulation of p27KIP1 and Bim gene expression, suggesting that the oncogenic tyrosine kinase FLT3 can negatively regulate FOXO transcription factors through the phosphorylation of FOXO3a leading to suppression of its function, thereby promoting the survival and proliferation of AML cells [54]. Here, FOXO3 is linked to acute myeloid leukemia.