FLT3 and acute myeloid leukemia: Quite recently, it was reported that Dnmt3A mutations were detected in 62 of 281 AML patients (22.1%), and these mutations were highly enriched in a group of patients with an intermediate-risk cytogenetic profile as well as FLT3 mutations (25 of 61 patients, 41.0%; P < 0.003) [6].