Interestingly, the use of anastrozole is associated with a higher incidence of arthralgias and inflammatory arthropathies than either placebo or tamoxifen, and Laroche et al found antinuclear antibodies (titer > 1:160) in nine of twenty-four women treated with aromatase inhibitors who developed arthralgias [13]. Here, CYP19A1 is linked to Arthralgia.