Patients with recurrent disease in cohort B tended to have less lymph node metastases, were more likely to have HR-positive disease, and had a longer disease-free interval compared with those in cohort A. In this study, 3 of the 60 patients with HER-2-positive disease (5%) received trastuzumab and 22 of the 167 patients with HR-positive disease (13%) received aromatase inhibitors as adjuvant therapy in cohort B. In these populations, the effect of these new agents may be attenuated. The gene discussed is ERBB2; the disease is metastatic malignant neoplasm in the lymph nodes.