S100A8 and metastatic melanoma: Interestingly, there was also high ranking of an early Th2 tumor-promoting environment demonstrated by presence of the IL13RA2 gene and the Th1 inhibiting cytokine IL10. The smaller amount of immunological information captured in the comparison of primary to metastatic melanoma (Figure 6) was attributable not to high scoring leukocyte or inflammation markers, but by upregulation of immunogenic melanoma antigens (MAGEA2/3) and downregulation of apoptosis inducing S100A8/9 cytokines.