It has been previously shown that TNFα released from ischemic heart after acute MI, has been shown to reduce contractility, increases the production of other cytokines such as IL-1, IL-6 and TIMP-1, induces pathophysiological hypertrophy, promotes apoptosis of cardiomyocytes and other alterations of the extracellular matrix which finally accelerates LV remodeling [26]. This evidence concerns the gene TIMP1 and benign neoplasm.