Several of the mutations observed in MeCP2 associated with RTT are located near putative phosphorylation sites – mutation of the Arg110 residue could alter the phosphorylation of Ser113 by PKCα/β, mutation of Arg294 might affect phosphorylation of Ser292 by PKCε or PKCδ, and mutations of Arg168 could impair Ser164 phosphorylation by CDKL5 (Fig. 4). The gene discussed is CDKL5; the disease is Rett syndrome.