Several of the mutations observed in MeCP2 associated with RTT are located near putative phosphorylation sites – mutation of the Arg110 residue could alter the phosphorylation of Ser113 by PKCα/β, mutation of Arg294 might affect phosphorylation of Ser292 by PKCε or PKCδ, and mutations of Arg168 could impair Ser164 phosphorylation by CDKL5 (Fig. 4). Here, MECP2 is linked to Rett syndrome.