The term “non–HFE-related HH” refers to several genetically distinct forms of inherited iron overload affecting individuals without HFE mutations.17 Several of the genes involved are hemojuvelin (HJV), ferroportin (SLC40A1), transferrin receptor 2 (TFR2), and hepcidin (HAMP). The gene discussed is SLC40A1; the disease is Tangier disease.