Zabouo et al. showed that METCAM/MUC18 is expressed in a subset of epithelial cells in malignant breast cancer and that it may contribute to tumor aggressiveness by promoting malignant cell motility (anti-METCAM/MUC18 antibodies decreased motility of MDA-MB-231 cells and transmigration of the same cells through established human endothelial cell layers and reduced the ability of the cells in healing a wound) [14]. The gene discussed is MCAM; the disease is neoplasm.