INS and metabolic syndrome: In ER/PR-positive patients, adiponectin and metabolic syndrome did not show any significant trends (all P for trend > 0.05) whereas HOMA-IR (P-value for trend = 0.022 in model 1, 0.016 in model 2) and insulin (P-value for trend = 0.046 in model 1, 0.036 in model 2) showed negative trends.