Diabetic hypertensive (DH) rats which fed on a HFD, injected with streptozotocin (STZ) (i.p.)and obstruction for its right kidney was occurred develop hyperglycemia, hypertension, cardiac fibrosis, hypertriglyceridemia, hypercholesterolemia, increased TNF-α, increased TGF-β, decreased MMP-2, increased collagen-I and increased collagen-III, when compared to rats fed on control diet. The gene discussed is MMP2; the disease is Hyperglycemia.