When quantified relative to IgM (loading control), the normalized intensity for upper immunoreactive band for NP was found to be significantly elevated in PDAC sera (n = 35, p<0.01, two-sided t-test using log-transformed data) compared to benign controls (n = 20, Figure 3F), while it was undetectable in a subset of sera from other tumor types (Figure S5). This evidence concerns the gene PNP and neoplasm.