DDX3X and breast cancer: In MDA-MB-231, a highly aggressive metastatic breast cancer cell line, DDX3 was found within an anti-apoptotic complex consisting of glycogen synthase kinase 3 (GSK3) and cellular inhibitor of apoptosis 1 (c-IAP1), which is an indication of its importance in the therapeutic resistance of tumor cells to TRAIL receptor antibody therapy [23].