siRNAstargeting POLB, LIG3, and XRCC1 inhibited HIV infection by more than 50%.Although long path BER enzymes have been used to model repair of HIV integrationintermediates in vitro [15], siRNAs targeting these genes had little effect onHIV infection (Figure 1C andTable 1). The gene discussed is XRCC1; the disease is infection.