CRP and Hypoalbuminemia: Over the last 10 years, laboratory markers of a systemic inflammatory response, including plasma C-reactive protein concentration (CRP), hypoalbuminaemia and Glasgow Prognostic Score (GPS, which combines CRP and albumin), and absolute white cell or its components (neutrophils, neutrophil/lymphocyte ratios (NLRs) and platelet/lymphocyte ratios (PLRs)) have been investigated as prognostic and predictive markers in different cancer populations, with the best evidence for their use demonstrated in surgical patients with CRC (Roxburgh and McMillan, 2010).