The OPCML hypermethylation has been reported in several cancers for example, 33.3% of late stage ovarian cancer (Teodoridis et al, 2005), 70% of hepatocellular carcinoma (Liu et al, 2006a), 63.9% of invasive cervical cancer (Ye et al, 2008) and 57–100% of multiple carcinomas and lymphomas (Cui et al, 2008). This evidence concerns the gene OPCML and hepatocellular carcinoma.