Since the Slc39a14-KO mice showed dwarfism, which is also seen in GH-deficient mouse models and humans [19], we investigated the role of SLC39A14 in signaling through growth hormone releasing hormone (GHRH) receptor (GHRHR), a GPCR expressed on pituitary somatotroph cells that induces the production and secretion of GH upon stimulation [27], [43]. This evidence concerns the gene GH1 and Severe short stature.