Our analyses of acceleration and TFBS divergence also highlighted several differentially expressed genes potentially involved in human cortex development and disease, such as WBSCR17 (candidate gene of the cognitive Williams-Beuren syndrome)[49], NLGN1 (implicated in synapse formation and autism)[50], PDE4IP (implicated in control of brain size or human microcephaly)[51], [52], MDGA1 and EFNA5 (guidance factors involved in cortical patterning) [53], [54], [55]. This evidence concerns the gene EFNA5 and microcephaly.