The effect of NF-κB deficiency in glial cells on severity of motor neuron disease was examined using cohorts of GFAP-IκBαAA (indicated as Tg), SOD1G93A (indicated as G93A) and GFAP-IκBαAA/SOD1G93A (indicated as double Tg) transgenic mice. This evidence concerns the gene GFAP and motor neuron disorder.