First, they express the most important glutamate transporter EAAT2/GLT-1, thus contributing to the clearance of this neurotransmitter; deficiency of astroglial EAAT2/GLT-1 causes severe motor neuron loss [12] and alteration of this transporter has been repeatedly invoked as a cause contributing to ALS [3]. Here, SLC1A2 is linked to amyotrophic lateral sclerosis.