PRNP and variant Creutzfeldt-Jakob disease: As illustrated in Figure 5, large plaque-like PrP deposits were detected throughout the brain, predominantly in the cerebral cortex, corpus callosum, thalamic nuclei, optic tract, brain stem and cerebellum, a distribution which is similar to that seen in the brains of vCJD-infected tg650 mice (Figure 5 and [35]).