Similar results were obtained when the immunoblots were performed with the 12B2 anti-PrP antibody, whose epitope (89WGQGG93 according to the human PrP sequence) is known to be poorly protected from proteinase K digestion [29], [37] in vCJD and BSE-related isolates (Figure 4). Here, PRNP is linked to variant Creutzfeldt-Jakob disease.