Further, identification of vtRNA-positive cells by in situ hybridization indicated that the well-delineated splenic follicles of M3.MR-infected mice were heavily populated with latently infected cells, and that these cells were rare outside follicles (Fig. 5C), comparable to what we had observed upon infection with wild-type MHV-68 [22]. The gene discussed is NR3C2; the disease is infection.