ARG1 and skin infection: The Th2-like environment in the skin infection site of 4x mice appeared to triggerswitching of dermal MΦ from being ‘classically-activated’(CAMΦ) to ‘alternatively-activated’ as quantitative (q)RT-PCRanalysis of mRNA from 4x DEC showed that transcripts for Arg-1, Ym1 and RELMα,which typically characterise AAMΦ [23], [24], [25], were all significantlyup-regulated compared to 1x DEC (Figure4B).