Only patients with clinical characteristics predictive of response to EGFR TKIs were enrolled (adenocarcinoma histology; nonsmokers, defined as patients who had smoked <100 cigarettes in their lifetime; or former light smokers, defined as those who had stopped smoking at least 15 years previously and had a total of ≤10 pack-years of smoking). The gene discussed is EGFR; the disease is adenocarcinoma.