In order to determine if common network deficits were created by schizophrenia-related genes, we studied the impact of gene knockdown on neuronal networks grown on MEAs using siRNAs and targeted three genes associated with schizophrenia: TRAF2 and NCK interacting kinase (Tnik), Discs Large Homolog 2 (Dlg2/PSD-93), and Disrupted in Schizophrenia 1 (Disc1), as well as a candidate gene for bipolar disorder (BD), Dynactin 5 (Dctn5). This evidence concerns the gene DISC1 and bipolar disorder.