To this end, experiments were conducted with CXCL-10-/- and wild type C57BL/6 mice and they were infected with Plasmodium berghei ANKA, a rodent malaria parasite commonly used as murine CM to ascertain the role of Foxp3, IL-10 and IL-2 in fatal CM pathogenesis. This evidence concerns the gene CXCL10 and malaria.