To comprehensively study the genetic variants of PTTG1 associated with susceptibility to pituitary adenomas, we genotyped five PTTG1 haplotype-tagging SNPs (htSNP) using PCR-RFLP in a case-control study, which included 280 pairs of age-, gender- and geographically matched Han Chinese people. The gene discussed is PTTG1; the disease is pituitary gland adenoma.