The most important differential diagnoses in this clinical pathological context (tumors involving the intestinal wall) are with gastrointestinal stromal tumor (GIST) and schwannoma.6,7 GISTs are usually composed of bland spindle and/or epithelioid cells without the uniquely perivascular location of the tumor cells that was seen in the present case, and over 95% of GISTs are positive for CD117 (KIT), while often negative for EMA. The gene discussed is MUC1; the disease is schwannoma.