Important histopathological evidence that calcific aortic valve stenosis develops in the same way as seen in atherosclerosis was reported by O'Brien et al.,3 who found that apolipoproteins B and E were present in early lesions and advanced aortic valve stenosis, but not in the region of normal valves, and found the same pattern of lipoproteins in coronary atherosclerosis.2,3. The gene discussed is APOB; the disease is aortic valve stenosis.