ALB and diabetes mellitus: Other conditions that contribute towards uneven biodistribution of medicines among the elderly are the following: (1) plasma albumin concentration tends to be lower than in young adults, thereby lowering the binding capacity of drugs and resulting in increased plasma-free fractions and increased volume of distribution; and (2) progressive reduction in the capacity for renal excretion (due to the normal aging process and/or chronic diseases like hypertension and diabetes mellitus), thereby prolonging the half-life of drugs and increasing the likelihood of adverse effects.11