It has been shown thatHath-1 expression is increased when the Wnt pathway isinhibited [26] andthat Hes-1 is a direct target of canonical Wnt signaling incolorectal adenomas and carcinomas [29], [31] Furthermore, Jagged-1 has been shown to represent amolecular link between Wnt and Notch in CRC, where the Jagged-1gene is directly regulated by β-catenin/Tcf-4 [32]. The gene discussed is HES1; the disease is colorectal carcinoma.