In our HT29 cell line model, preliminary results cannotconfirm that β-catenin is a Notch target in CRC cells since we do not see anyeffects on β-catenin or its target cyclin D1 by DAPT treatment(blocking of intracellular Notch signaling) (Fig. S4A and B). This evidence concerns the gene CCND1 and colorectal carcinoma.