van Es et al. [3] have demonstrated that blockageof Notch in the context of overactive Wnt signaling leads to the differentiation ofproliferative mouse intestinal tumors into post-mitotic goblet cells and reducedtumor growth, something Peignon et al. [31] failed to corroborate in aconditional model where both the Apc and RBJ-κgenes were deleted simultaneously, the latter reflecting a model of more acute Apcloss. This evidence concerns the gene DNAJC27 and intestinal neoplasm.