Recently, Rodillaand co-workers [32] performed a study where they blocked Wnt signalingthrough β-catenin in Ls17T CRC cells using a dominant negative (dn) Tcf-4inducible vector and identified transcriptional targets using microarray mRNAexpression profiling and quantitative RT-PCR. This evidence concerns the gene HNF4A and colorectal carcinoma.