Consistent with this notion, we recently found significantly higher frequency of CT mRNA expression in estrogen receptor (ER) and progesterone receptor (PR) negative breast cancer cell lines and primary breast cancers, including MAGE-A3, MAGE-A6, NY-ESO-1, MAGE-A12, LAGE-1, CSAG2 etc [12]. The gene discussed is CTAG2; the disease is breast cancer.