SOD1 and amyotrophic lateral sclerosis: Mutations in the enzyme superoxide dismutase-1 (SOD1) cause hereditary variantsof the fatal motor neuronal disease Amyotrophic lateral sclerosis (ALS).Pathophysiology of the disease is non-cell-autonomous: neurotoxicity is derivednot only from mutant motor neurons but also from mutant neighbouringnon-neuronal cells.