It was reported that over-expression of ADAMTS-1 promotedpulmonary metastasis of TA3 mammary carcinoma and Lewis lung carcinoma cells[21], andforced expression of ADAMTS-5 in glioma cell lines stimulated cell invasion[22].In addition, matrix metalloproteinase-2 (MMP-2), an enzyme which degradedtype IV collagen, was decreased in Cr(VI) transformed cells. This evidence concerns the gene ADAMTS5 and central nervous system cancer.