The present results demonstrate that the PDGFR-β KO mice share behavioral and neuroanatomical features that are typical of major psychiatric disorders, especially the negative symptoms of schizophrenia, socioemotional disturbances of autism (i.e., abnormalities in social interaction, sensorimotor gating, and cognition), and reduced number of parvalbumin-positive interneurons. Here, PDGFRB is linked to autism.