A comparison of the numbers of CD25+Foxp3+ Tregs and CD3+Foxp3+ and CD8+Foxp3+ in TILs between oral SCCs and 15 human tumor-free tonsils again revealed an increased number of Tregs in carcinomas whereas no significant change was noted in the number of CD3+Foxp3+ and CD8+Foxp3+ in TILs [139]. This evidence concerns the gene FOXP3 and carcinoma.