RAD-001, acting in a similar manner than rapamycin through the inhibition of mTORC1 complexes, is currently tested in various clinical trials for renal cell carcinoma (RECORD program), advanced papillary tumours (RAPTOR), metastatic neuroendocrine tumours (RAMSETE), or breast cancers (BOLERO). The gene discussed is RRAD; the disease is breast carcinoma.