It is likely that a suite of biomarkers, both in the host and tumor [73] will be required rather than single biomarker selection, with some candidates for study in RMS including IGF2, pIGF1R/IGF1R, IGF1, pIRS-1/IRS-1, pIR-A/IR-A, IGFBP-6, and maybe others such as HSPs, PDGFR and Erb2. Here, IGFBP6 is linked to neoplasm.