CD34 and chronic myelogenous leukemia, BCR-ABL1 positive: As already noted, prominin-1 (CD133) is the most downregulated gene in CML CD34+ G0 cells compared to normal G0 cells and expression of the CD133/2 antigen is also low in both CML CD34+ G0 and G1/S/G2/M and Bcr-Abl driven All-3 cells compared to normal bone marrow or cord blood CD34+ G0 and G1/S/G2/M cells (Figure 3).