PROM1 and chronic myelogenous leukemia, BCR-ABL1 positive: In summary, based on our observations so far, it appears that Prominin-1, the product of the gene most downregulated in CML CD34+ G0 cells, is also underexpressed on the surface of both CML CD34+ G0 and G1/S/G2/M compared to normal bone marrow or cord blood CD34+ G0 and G1/S/G2/M cells (Figure 3).