It is also evident in Figure 2(a) that CML total CD34+ and CD34+ G0 cells produced more total colonies than the corresponding normal cells when stimulated by the three early acting cytokines KL, FL, and TPO and to a lesser extend by KL+G− and GM-CSF, again showing the CML progenitors are more easily triggered into cycle than the normal cells. Here, TPO is linked to chronic myelogenous leukemia, BCR-ABL1 positive.