The most striking difference is in the number of genes upregulated in the CML/G0 cells that are either involved in DNA replication (TOPO2a, RRM2, GINS1 and 2) or are part of the mitotic spindle machinery (MAP9, CETN3, ANLN, DLG7). Here, RRM2 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.