At higher concentrations, the Abl TKI inhibitors are lethal to both fresh primary CML progenitors and Bcr-Abl-driven cell lines while at still higher concentrations, they also kill normal progenitors and cell lines not driven by Bcr-Abl, the exact normal: CML lethal concentration ratios depending on the particular cells and inhibitors. The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.