The atypical Rho protein Rnd3/Rho8/RhoE is an important regulator of migration of fibroblasts and tumor cells (Chardin, 2006; Guasch et al., 1998; Klein and Aplin, 2009; Nobes et al., 1998) that acts by inhibiting RhoA through stimulation of the Rho GTPase-activating protein p190RhoGAP (Wennerberg et al., 2003), and/or inhibition of the activity of ROCKI, one of the main effectors of RhoA (Riento et al., 2003). The gene discussed is RHOA; the disease is neoplasm.