RHOA and melanoma: The finding that Rnd3 promotes migration of cortical neurons through inhibition of RhoA activity was not surprising, because it uses the same mechanism to regulate the migration of fibroblasts, melanoma cells, and other cell types in culture (Chardin, 2006; Guasch et al., 1998; Klein and Aplin, 2009; Riento et al., 2005b).