From the descriptions provided, the portion of the statin users that were on their medication prior to their myocardial infarction or angiographically defined coronary artery disease cannot be determined for Ottawa Heart Genomics Studies and the various studies used by Assimes et al. The statin usages cited above would include more aggressive lipid interventions subsequent to the event, and post-incident statin use may actually prevent the loss of KIF6 719Arg carriers among cases. The gene discussed is KIF6; the disease is coronary artery disorder.