First, EBERs themselves binds to PKR in vitro, a key mediator of the antiviral effect of IFNs, and inhibit PKR- or IFNα-mediated apoptosis [31] (Figure 2), although in BL cells, EBER inhibition of PKR-mediated apoptosis is likely not accomplished by direct inhibition of PKR [76]. This evidence concerns the gene EIF2AK2 and Burkitt lymphoma.